Associate Professor Sanjay Patel

MBBS, PhD, FRACP
Our treatment mission is to bypass arterial blockages by stimulating new blood vessel growth, to restore blood flow to affected regions.

Dr Patel completed his PhD in lipid biology in 2009 at the HRI and his post doctoral studies at Stanford University in 2010. He is currently appointed as an Interventional Cardiologist at Royal Prince Alfred Hospital, while simultaneously pursuing translational and clinical research in atherosclerotic heart disease, supported by funding from NHMRC and Sydney Medical School Foundation Grants.

Current Appointments

Cell Therapeutics Group Leader

Heart Research Institute

Head, Coronary Radial Program, Department of Cardiology

Royal Prince Alfred Hospital

Faculty member

Coronary Physiology and Imaging Masterclass Program, Sydney

Assessor

NHMRC project grants

Editorial research reviewer

Interventional Cardiology

Associate Professor Sanjay Patel leads group:
Research covers areas of:
Contact Associate Professor Sanjay Patel

More about Dr. Sanjay Patel

Research Project Opportunities
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Cardiovascular regeneration using induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) are a novel stem cell type that holds great promise in augmenting cardiovascular regeneration.

Differentiation of iPSCs to iPSC-ECs: The reprogrammed cells will be characterised in vitro to confirm their pluripotentiality.To initiate differentiation, the iPS cells will be cultured in non-adhesive dishes to form embryoid body aggregates that can spontaneously differentiate.

The cells are then dissociated and purified for the EC-specific markers vascular endothelial (VE)-cadherin and PECAM-1 by FACS. The EC phenotype of the iPS-derived ECs is confirmed by gene expression assays. Our group also has experience in generating an EC-specific reporter construct for purification and bioluminescence tracking of ECs. These novel techniques therefore allow for dynamic tracking of ECs in vitro and in vivo.

Assessment of the function of iPS-derived ECs in vitro: Established methods will be employed to characterise the function of these cells, including assays for cell proliferation, cell migration, and tube formation in matrigel. We will further assess incorporation of iPS-ECs into biosynthetic hydrogels to form functional vascularised tissue.

In vivo assessment of iPS-EC function: The mouse hindlimb ischaemia model has been well characterised in our laboratory, and the effects of these cells in promoting expansion of the microvasculature and tissue perfusion will be assessed. Moreover, the ability of iPSC-ECs to promote wound healing in
a mouse tissue injury model will be evaluated.

Featured Publication
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Gray, B, Klimis, H, Inam, S, Ariyathna, N, Kumar, S, Bailey, B, Patel, S, 2014, 'Radiation exposure during cardiac catheterisation is similar for both radial and femoral approaches' Heart Lung Circ, vol.24, pp. 264-269.

Paper challenged current practice of femoral approach coronary angiography being safer from a radiation exposure perspective, resulting in a change of practice in the RPAH cardiac catheterisation laboratory, regarding choice of access for coronary angiography. This, in turn, has lead to a decrease in vascular complications associated with angiography.

Current Research Grants
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Novartis Commercial Funding, Aflibercept Project, 2014-2015
Novartis Commercial Funding, VEGF Project, 2014-2015
Awards for Research
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2013     Medical School Foundation Grant
2012     Fellow of the Cardiac Society of Australia and New Zealand
2011     Pfizer Cardiovascular Research Grant, Project: “Immunomodulatory Effects of T Regulatory Cells in Atherosclerosis”
2010     Overseas Biomedical Fellowship, National Health and Medical Research Council of Australia, Project: “The Use of Induced Pluripotential Cells to Augment In Vivo Angiogenesis”
2009     Bushell Travelling Fellowship, Royal Australasian College of Physicians
2008     Travel Grant to attend annual meeting, Cardiac Society of Australia and New Zealand
2008     Finalist Young Investigator Award Clinical Section (Ralph Reader Prize), Cardiac Society of Australia and New Zealand
2008     Young Investigator Award (Patron’s Prize), Royal Prince Alfred Hospital
2008     Pfizer Major Cardiovascular Lipid Travel Grant
2008     Arteriosclerosis Thrombosis Vascular Biology Merit Award for Young Investigators
2008     Travel Grant to attend American Heart Meeting, Cardiac Society of Australia and New Zealand
2008     Travel Grant to attend American Heart Meeting, National Heart Foundation of Australia
2008     The RPA Cardiologist’s Award for the Best Clinical Science Paper by a Heart Research Institute Scientist, Heart Research Institute
2007     Travel Grant to attend American Heart Meeting, National Heart Foundation of Australia 
2006     Fellow of the Royal Australasian College of Physicians
2005     Postgraduate Research Scholarship, National Heart Foundation of Australia
2009     University of Sydney, Doctor of Philosophy, “The Anti-Inflammatory Effects of High Density Lipoproteins in Atherosclerosis”
2008     United States Medical Licensing Examination Part 1, Part II Clinical Knowledge, Part II Clinical Skills (ECFMG certified 0-634-591-2)
2003     Passed FRACP Written and Clinical Examination (1st attempt)
1999     University of Sydney, Bachelor of Medicine Bachelor of Surgery, First Class Honours, Distinctions in Final Year Medicine and Surgery